Please use this identifier to cite or link to this item:
Title in Portuguese: Association between human papillomavirus (HPV) and the oral squamous cell carcinoma : a systematic review
Author: Lima, Marcos Antonio Pereira de
Silva, Cláudio Gleidiston Lima da
Rabenhorst, Silvia Helena Barem
Keywords: Carcinoma de Células Escamosas
Neoplasias Bucais
Issue Date: Feb-2014
Publisher: Jornal Brasileiro de Patologia e Medicina Laboratorial
Citation: LIMA, M. A. P. ; SILVA, C. G. L. ; RABENNHORST, S. H. B. Association between human papillomavirus (HPV) and the oral squamous cell carcinoma : a systematic review. Jornal Brasileiro de Patologia e Medicina Laboratorial, Rio de Janeiro, v. 50, n. 1, p. 75-84, fev. 2014.
Abstract: The human papillomavirus (HPV) is an epitheliotropic agent whose high-risk genotypes have a well-established link with the development of cervical cancer. Although the relation of HPV to the oral squamous cell carcinoma (OSCC) has been studied since the beginning of the 1980s, its role in the oral carcinogenesis and the probable underlying molecular mechanisms are still not fully elucidated. We performed a systematic review of the worldwide scientific literature, published until the preparation of the present paper, concerning the association of HPV with OSCC, scrutinizing the samples, prevalence levels, the techniques utilized and relevant findings of the studies. The results showed that HPV is associated with approximately one quarter of OSCCs. Another interesting feature is the distinct pattern of infection in these oral tumors, including the participation of genotypes that are uncommon in cervical malignant lesions, such as HPV-38, 44, 53 and 70. Equally interesting is the possibility of carcinogenic action without the occurrence of viral integration, verified by the high expression of messenger ribonucleic acid (mRNA) of E6 and E7 from high-risk genotypes in cases whose virus remain in the episomal form. These findings support the assumption of HPV involvement in the genesis of OSCC, whereas warn about the possibility of unexpected viral behaviors that sometimes are not perceived or understood due to the technological limitations of the time and to the shortage of studies with the adequate approaches.
ISSN: 1676-2444
Appears in Collections:DPML - Artigos publicados em revista científica

Files in This Item:
File Description SizeFormat 
2014_art_cglsilva.pdf392,41 kBAdobe PDFView/Open

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.