Please use this identifier to cite or link to this item: http://www.repositorio.ufc.br/handle/riufc/9908
Title in Portuguese: The participation of the nitrergic pathway in increased rate of transitory relaxation of lower esophageal sphincter induced by rectal distension in dogs
Author: Palheta, Michel Santos
Graça, José Ronaldo Vasconcelos da
Santos, Armênio Aguiar dos
Lopes, Liziane Hermógenes
Palheta Júnior, Raimundo Campos
Souza, Miguel Ângelo Nobre e
Keywords: Óxido Nítrico
Refluxo Gastroesofágico
Issue Date: Apr-2014
Publisher: Arquivos de Gastroenterologia
Citation: PALHETA, M. S. et al. The participation of the nitrergic pathway in increased rate of transitory relaxation of lower esophageal sphincter induced by rectal distension in dogs. Arquivos de Gastroenterologia, São Paulo, v. 51, n. 2, p. 102-106, abr. 2014.
Abstract: Context - The rectal distension in dogs increases the rate of transitory lower esophageal sphincter relaxation considered the main factor causing gastroesophageal reflux. Objective - The aim of this study was evaluate the participation of the nitrergic pathway in the increased transitory lower esophageal sphincter relaxation rate induced by rectal distension in anesthetized dogs. Methods - Male mongrel dogs (n = 21), weighing 10-15 kg, were fasted for 12 hours, with water ad libitum. Thereafter, they were anesthetized (ketamine 10 mg.Kg-1 + xylazine 20 mg.Kg-1), so as to carry out the esophageal motility evaluation protocol during 120 min. After a 30-minute basal period, the animals were randomly intravenous treated whith: saline solution 0.15M (1ml.Kg-1), L-NAME (3 mg.Kg-1), L-NAME (3 mg.Kg-1) + L-Arginine (200 mg.Kg-1), glibenclamide (1 mg.Kg-1) or methylene blue (3 mg.Kg-1). Forty-five min after these pre-treatments, the rectum was distended (rectal distension, 5 mL.Kg-1) or not (control) with a latex balloon, with changes in the esophageal motility recorded over 45 min. Data were analyzed using ANOVA followed by Student Newman-Keuls test. Results - In comparison to the respective control group, rectal distension induces an increase in transitory lower esophageal sphincter relaxation. Pre-treatment with L-NAME or methylene blue prevents (P<0.05) this phenomenon, which is reversible by L-Arginine plus L-NAME. However, pretreating with glibenclamide failed to abolish this process. Conclusion - Therefore, these experiments suggested, that rectal distension increases transitory lower esophageal sphincter relaxation in dogs via through nitrergic pathways.
URI: http://www.repositorio.ufc.br/handle/riufc/9908
metadata.dc.type: Artigo de Periódico
ISSN: 0004-2803
Appears in Collections:DFIFA - Artigos publicados em revista científica

Files in This Item:
File Description SizeFormat 
2014_art_rcpalhetajunior.pdf283,16 kBAdobe PDFView/Open


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.