Please use this identifier to cite or link to this item:
Title in Portuguese: The treadmill exercise protects against dopaminergic neuron loss and brain oxidative stress in parkinsonian rats
Author: Costa, Roberta Oliveira da
Gadelha-Filho, Carlos Vinicius Jataí
Costa, Ayane Edwiges Moura da
Feitosa, Mariana Lima
Araújo, Dayane Pessoa de
Lucena, Jalles Dantas de
Aquino, Pedro Everson Alexandre de
Lima, Francisco Arnaldo Viana
Neves, Kelly Rose Tavares
Viana, Glauce Socorro de Barros
Keywords: Doença de Parkinson
Parkinson Disease
Issue Date: Jun-2017
Publisher: Oxidative Medicine and Cellular Longevity
Citation: COSTA, R. O. da et al. The Treadmill Exercise Protects against Dopaminergic Neuron Loss and Brain Oxidative Stress in Parkinsonian Rats. Oxidative Medicine and Cellular Longevity, v. 2017, p. 1-10, jun. 2017.
Abstract: Parkinson’s disease (PD), a progressive neurological pathology, presents motor and nonmotor impairments. The objectives were to support data on exercise benefits to PD. Male Wistar rats were distributed into sham-operated (SO) and 6-OHDA-lesioned, both groups without and with exercise. The animals were subjected to treadmill exercises (14 days), 24 h after the stereotaxic surgery and striatal 6-OHDA injection. Those from no-exercise groups stayed on the treadmill for the same period and, afterwards, were subjected to behavioral tests and euthanized for neurochemical and immunohistochemical assays. The data, analyzed by ANOVA and Tukey post hoc test, were considered significant for . The results showed behavioral change improvements in the 6-OHDA group, after the treadmill exercise, evaluated by apomorphine rotational behavior, open field, and rota rod tests. The exercise reduced striatal dopaminergic neuronal loss and decreased the oxidative stress. In addition, significant increases in BDNF contents and in immunoreactive cells to TH and DAT were also observed, in striata of the 6-OHDA group with exercise, relatively to those with no exercise. We conclude that exercise improves behavior and dopaminergic neurotransmission in 6-OHDA-lesioned animals. The increased oxidative stress and decreased BDNF contents were also reversed, emphasizing the importance of exercise for the PD management.
metadata.dc.type: Artigo de Periódico
ISSN: 1942-0900
1942-0994 (Online)
Appears in Collections:PPGF - Artigos publicados em revistas científica

Files in This Item:
File Description SizeFormat 
2017_art_rocosta.pdf4,96 MBAdobe PDFView/Open

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.