Please use this identifier to cite or link to this item: http://www.repositorio.ufc.br/handle/riufc/28084
Title in Portuguese: Role of the route of leukotrienes in an experimental model of oral mucositis induced by 5- fluorouracil 1
Author: Silva, Viviane Carvalho da
Leitão, Renata Ferreira de Carvalho
Brito, Gerly Anne de Castro
Martins, Conceição da Silva
Freire, Gildenio Estevam
Aragão, Karoline Saboia
Wanderley, Carlos Wagner de Souza
Freitas, Marcos Rabelo de
Keywords: Leucotrienos
Leukotrienes
Araquidonato 5-Lipoxigenase
Estomatite
Issue Date: Sep-2017
Publisher: Acta Cirurgica Brasileira
Citation: SILVA, V. C. da et al. Role of the route of leukotrienes in an experimental model of oral mucositis induced by 5-fluorouracil. Acta Cirurgica Brasileira, São Paulo, v. 32, n. 9, p. 712-725, sept. 2017.
Abstract: Purpose: To investigate the participation of cysteinyl leukotrienes in the pathophysiology of oral mucositis. Methods: Oral mucositis was induced in hamsters using 5-fluorouracil (5-FU; 60 and 40 mg/kg; i.p., on days 1 and 2, respectively, and with excoriations in jugal mucosa on day 4). Montelukast (10, 20, or 40 mg/kg/d; gavage), MK886 (3 mg/kg/d, i.p.), or saline or celecoxib (7.5 mg/kg/d; i.p.) was administered 1 h prior to 5-FU and daily, until the fourth (MK886) or tenth day, when the animals were euthanized and their jugal mucosa was collected for macroscopic, histopathological, and immunohistochemical evaluation. Results: Neither montelukast nor MK-886 prevented the oral mucositis induced by 5-FU, as observed by histopathological evaluation. In addition, we did not find significant differences in the expression of inducible nitric oxide synthase-2, cyclooxygenase-2, or interleukin (IL)-1β between the experimental and control groups. However, we did observe a significant decrease in tumor necrosis factor (TNF)-α expression for all doses of montelukast; we also observed a significant decrease in IL-10 with 40 mg/kg/d and MK 886. Conclusions: Cysteinyl leukotrienes do not play an important role in experimental oral mucositis induced by 5-FU. There is a modulating action specifically on TNF-α.
URI: http://www.repositorio.ufc.br/handle/riufc/28084
metadata.dc.type: Artigo de Periódico
ISSN: Print 0102-8650
On-line 1678-2674
Appears in Collections:PPGF - Artigos publicados em revistas científica

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