Please use this identifier to cite or link to this item: http://www.repositorio.ufc.br/handle/riufc/40262
Title in Portuguese: Lactobacillus reuteri DSM 17938 protects agains gastric damage induced by ethanol administration in mice: role of TRPV1/substance P axis
Author: Oliveira, Ana P.
Souza, Luan K. M.
Araújo, Thiago S. L.
Araújo, Simone de
Nogueira, Kerolayne M.
Sousa, Francisca Beatriz M.
Silva, Renan O.
Pacífico, Dvison M.
Martins, Conceição S.
Brito, Gerly Anne de C.
Souza, Marcellus H.L.P.
Medeiros, Jand Venes R.
Keywords: Gastrite
Gastritis
Etanol
Ethanol
Probióticos
Probiotics
Issue Date: Jan-2019
Publisher: Nutrients
Citation: OLIVEIRA, Ana P. et al. Lactobacillus reuteri DSM 17938 protects agains gastric damage induced by ethanol administration in mice: role of TRPV1/substance P axis. Nutrients, v. 11, n. 1, p. 1-16, jan. 2019.
Abstract: This study aimed to evaluate the effect of Lactobacillus reuteri DSM 17938 (DSM) on ethanol-induced gastric injury, and if its possible mechanism of action is related to inhibiting the transient receptor potential vanilloid type 1 (TRPV1). We evaluated the effect of supplementing 108 CFU g body wt􀀀1 day􀀀1 of DSM on ethanol-induced gastric injury. DSM significantly reduced the ulcer area (1.940 1.121 mm2) with 3 days of pretreatment. The effects of DSM supplementation were reversed by Resiniferatoxin (RTX), TRPV1 agonist (3 nmol/kg p.o.). Substance P (SP) (1 mol/L per 20 g) plus 50% ethanol resulted in hemorrhagic lesions, and DSM supplementation did not reverse the lesion area induced by administering SP. TRPV1 staining intensity was lower, SP, malondialdehyde (MDA) and nitrite levels were reduced, and restored normal levels of antioxidant parameters (glutathione and superoxide dismutase) in the gastric mucosa in mice treated with DSM. In conclusion, DSM exhibited gastroprotective activity through decreased expression of TRPV1 receptor and decreasing SP levels, with a consequent reduction of oxidative stress.
URI: http://www.repositorio.ufc.br/handle/riufc/40262
ISSN: 2072-6643
Appears in Collections:DFIFA - Artigos publicados em revista científica

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