Please use this identifier to cite or link to this item: http://www.repositorio.ufc.br/handle/riufc/49653
Title in Portuguese: An ab initio explanation of the activation and antagonism strength of an AMPA-sensitive glutamate receptor
Author: Martins, Ana Caroline Vieira
Lima Neto, Pedro de
Barroso Neto, Ito Liberato
Cavada, Benildo Sousa
Freire, Valder Nogueira
Caetano, Ewerton Wagner Santos
Keywords: Central nervous system
Amino acids
Electrophysiological
Issue Date: 2013
Publisher: RSC Advances
Citation: MARTINS, Ana Caroline Vieira; LIMA-NETO, Pedro de; NETO, Ito Liberato Barroso; CAVADA, Benildo Sousa; FREIRE, Valder Nogueira; CAETANO, Ewerton Wagner Santos. An ab initio explanation of the activation and antagonism strength of an AMPA-sensitive glutamate receptor. RSC Advances, v. 3, n. 35, p. 1-5, 2013.
Abstract: We report quantum biochemistry calculations focusing on the binding pocket of the glutamate receptor co-crystallized with agonists (full and partial) and a antagonist. The calculated electronic binding energy follows the order AMPA . glutamate. kainate . DNQX, which explains published experimental data on GluR2 activation and antagonism strength.
URI: http://www.repositorio.ufc.br/handle/riufc/49653
metadata.dc.type: Artigo de Periódico
ISSN: 2046-2069
Appears in Collections:DFI - Artigos publicados em revista científica

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