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Title in Portuguese: Impact of apolipoprotein E genetic polymorphisms on liver disease: an essential review
Author: Nascimento, José C.R.
Matos, Gabriella A.
Pereira, Lianna C.
Mourão, Anderson E.C.C.B.
Sampaio, Aline M.
Oriá, Reinaldo B.
Toniuttoc, Pierluigi
Keywords: Apolipoproteínas E
Apolipoprotein E
Liver cirrhosis
Cirrose Hepática
Liver diseases
Liver transplantation
Transplante de Fígado
Issue Date: Jan-2020
Publisher: Annals of Hepatology
Citation: NASCIMENTO, J. C. R. et al. Impact of apolipoprotein E genetic polymorphisms on liver disease: An essential review. Annals of Hepatology, v. 19, n. 1, p. 24-30, 2020. Disponível em: Acesso em: 20 abr. 2021.
Abstract: Cirrhosis is an advanced stage of liver disease, compromising liver function with systemic health implications and poor quality of life. Hepatitis C virus (HCV) infection and alcoholic liver disease are the main causes of this pathology. However, since genetic factors may play a large role in the progression and severity of liver disease, and as apolipoprotein E (apoE) has been recognised to be mainly synthesised in the liver, apoE polymorphism studies are important to better understand the causal mechanisms in liver diseases. In this review, we summarise up-to-date studies addressing how apoE polymorphisms influence liver cirrhosis and liver transplantation outcomes and potential protective mechanisms. Although more clinical studies are needed to support these findings, the apoE 4 allele seems to be protective against the progression of liver cirrhosis in the majority of aetiologies and the postoperative serum apoE phenotype of the transplanted subject receptors was converted to that of the donor, indicating that >90% of apoE in plasma is synthesised in the hepatic system.
metadata.dc.type: Artigo de Periódico
ISSN: 1665-2681
Appears in Collections:DMC - Artigos publicados em revistas científicas

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